HBeAg-negative hepatitis B in a previously thalassemic patient during immunosuppressive therapy for chronic GVHD
نویسندگان
چکیده
منابع مشابه
Hepatitis B surface antigen seroconversion in HBeAg negative chronic hepatitis B patient during entecavir treatment.
Chronic hepatitis B (CHB) infection is still a huge public health problem despite the development of new drugs for its treatment, and complications of end-stage liver disease due to this infection results in one million deaths worldwide annually (1). The ideal end-point of therapy is hepatitis B surface antigen (HBsAg) loss with or without HBs seroconversion. However, it is frequently not achie...
متن کاملAntiviral therapy leads to histological improvement in HBeAg-negative chronic hepatitis B patients
We read with great interest the study by Papachrysos et al showing that antiviral therapy leads to histological improvement in HBeAg-negative chronic hepatitis B patients [1]. We agree with the authors that long-term antiviral treatment with nucleos(t)ide analogs suppresses hepatitis B virus (HBV) replication, delays disease progression and contributes to resolution of fi brosis [2,3]. In patie...
متن کاملDifferential Plasma MicroRNA Profiles in HBeAg Positive and HBeAg Negative Children with Chronic Hepatitis B
BACKGROUND AND AIM Children chronically infected with hepatitis B virus (HBV) are at high risk of progressive liver disease. However, no treatment is available that is consistently effective in curing chronic hepatitis B (CHB) in children. Improved understanding of the natural course of disease is warranted. Identification of specific microRNA (miRNA) profiles in children chronically infected w...
متن کاملComparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients
BACKGROUND Chronic hepatitis B consists of different clinical phases. Laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. OBJECTIVES This study was conducted to determine laboratory and histological characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B patients. PATIENTS AND METHODS In this...
متن کاملAntiviral therapy leads to histological improvement of HBeAg-negative chronic hepatitis B patients
BACKGROUND We investigated hepatic histological changes in a cohort of HBeAg-negative chronic hepatitis B (CHB) patients (n=50) under long-term antiviral treatment in clinical practice. METHODS Liver biopsies were obtained at baseline and after prolonged antiviral treatment with lamivudine (42/50), entecavir (6/50), telbivudine (1/50), or tenofovir (1/50). Due to viral resistance to lamivudin...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 1998
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1701433